Importance of Research

Basic laboratory research is critical to discovering the ways a normal brain becomes an epileptic brain and to finding better ways to stop seizures. While it is known that epilepsy is an imbalance between excitatory and inhibitory processes, we currently do not understand how a genetic abnormality or an injury to the brain gives rise to epilepsy.

Research has shown that the processes leading to seizures, known as epileptogenesis, involve changes in gene expression, the "rewiring" of brain connections, and the death or birth of specific brain cells. Additional research is needed to more fully understand how seizures start, spread and stop, and how antiepileptic drugs (AEDs) work on brain cells to block seizures.




SEHRF Projects: Supporting Cutting Edge Research



Functional Studies

Uncovering the effects of changes in molecules, channels and brain cells in epilepsy and brain disorders




ANIMAL MODELS

Understanding and testing treatments that we can apply to humans




OMICS

Discovering the cellular pathways that underlie childhood epilepsy and brain disorders




NEURONAL CELL LINES (iPSC)

Translating discoveries from human cells to human lives




SCN8A REGISTRY

You can help SEHRF advance the scientific understanding of SCN8A by supporting the Registry.

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